Self-inflicted loss and spiritual ruin

أُو۟لَـٰٓئِكَ ٱلَّذِينَ خَسِرُوٓا۟ أَنفُسَهُمْ وَضَلَّ عَنْهُم مَّا كَانُوا۟ يَفْتَرُونَ

Those are the ones who will have lost themselves, and lost from them is what they used to invent.